Written by Amal Allam
Saturday, May 13, 2023 12:17 PM
Scientists have discovered a bat protein that can slow aging and even fight corona, heart disease and arthritis, and the protein was found ASC2 to stop the inflammatory response in bats, according to the British Daily Mail.
The researchers said that human drugs can be made to mimic a protein ASC2which is found in bats, where a study found that a protein from bats could contain the key to slowing human aging and fighting conditions such as corona, heart disease, and arthritis. Bats live about 20 years on average, and are not harmed by deadly human pathogens such as Ebola and Corona, This has led scientists to investigate animals to see if their ability to adapt to disease can work in humans as well, as researchers at the College of Medicine discovered. Duke-NUS Singaporeans have a protein responsible for their amazing immune defense.
It showed promising results in genetically modified mice and scientists hope it can eventually be used in humans to save millions of lives. Researchers have found a modified version of a protein called “bat ASC2” which stops the inflammatory response in bats and gives them viral resilience.
Our results demonstrate an important mechanism by which bats reduce excessive virus-induced and stress-related inflammation, with implications for their longevity, the team writes..
They genetically modified mice to carry a protein ASC2 which then showed the same defensive properties against inflammation as bats, according to their study published in the journal Cell They were investigating why bats are so good at fending off viruses.
when they tested the bat protein ASC2 On human cells, the cells became more resistant to disease, illustrating their ‘therapeutic potential’.
-Linfa Wang, professor of emerging infectious diseases at Duke University School of Medicine, told The Telegraph The Telegraph The bat protein ASC2 It could be the secret to longevity and reduced mortality from viruses in humans, he added, but it may not be the only factor.
-Dr Wang said the new discovery could mean that human drugs can be made to mimic a protein ASC2 It could then treat multiple viruses that produce an inflammatory response in humans.
He added, “We have filed patents based on this work and are exploring commercial partnerships for drug discovery. We hope to develop a new class of anti-inflammatory drugs for diseases caused by human infections. In mice, the death rate from the deadly influenza virus was cut in half from 100% to 50% in those who have protein adaptations ASC2
In addition, protein hindered ASC2 Zika virus, a mosquito-borne virus first discovered in Africa, also in transgenic mice.
This protein is carried by both humans and bats, but the researchers hypothesized that it becomes stronger in bats as they fly, putting their bodies under enormous physiological stress..
More research is needed, said Professor Gilda Tachidjian, chair of life sciences at the Burnet Institute in Australia, adding that bats may have evolved a way to subdue their inflammatory immune response to survive..
Professor Gilda Tachedjian, chair of life sciences at the Burnet Institute in Australia, told The Telegraph that the researchers proved the concept that bat protein ASC2 It can target the part of the immune system responsible for inflammatory responses, thus reducing inflammation in cells in the body.
She added that while the results of this study are interesting, more work is needed to translate these findings into new therapies that could be used in people to reduce deaths from viruses or increase longevity.
